Opposite the Town Hall, the street widens out into Piazza del Duomo, with the Cathedral of San Nicola. Founded by the Hohenstaufens in the 13th century and altered several times in the 15th to 17th centuries, it combines medieval and more recent features.
The unplastered exterior, with its crenellations, is original, whereas the Baroque main door was added in 1636 and matches the 1635 Baroque fountain in the middle of the square. The three aisles of the basilica are separated by large pillars supporting pointed arches.The interior is decorated with a number of works dating from the 15th and 16th centuries, including the 15th-century Visitation of the Virgin Mary by Antonio Giuffrè and Madonna and Child with Saints by Antonello da Saliba, painted in 1504.